CHIR99021
| Cat. No. | G7200 |
| Name | CHIR99021 |
| Description |
CHIR99021 is a highly selective and potent inhibitor of glycogen synthase kinase-3 (GSK-3α/β), widely used in stem cell research to regulate signaling pathways critical for cell survival, proliferation, and differentiation. By blocking GSK-3 activity, CHIR99021 stabilizes β-catenin and activates the Wnt/β-catenin pathway, making it an essential tool in pluripotent stem cell biology. In iPSC workflows, CHIR99021 is commonly applied to enhance reprogramming efficiency, maintain pluripotency, and direct differentiation into specialized lineages such as cardiomyocytes, neural precursors, and endodermal cells. Its high specificity for GSK-3 reduces off-target effects compared to older inhibitors, ensuring consistent and reproducible results in sensitive experiments. Key Features:
Applications:
Specifications:
|
| Unit | 5 mg |
| Usage |
Typical iPSC use: 2–3 µM (optimization required) |
| Storage Condition | Store at -20 °C, protect from light, desiccated. |
| Material Citation | If use of this material results in a scientific publication, please cite the material in the following manner: Applied Biological Materials Inc, Cat. No. G7200 |