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AAV siRNA Library
abm’s RNAi Expression System is available in AAV format, enabling efficient siRNA expression with non-integrating delivery for gene therapy. Featuring a unique convergent promoter design, it enhances gene knockdown without requiring a hairpin loop structure. The system includes a GFP reporter for transduction monitoring and offers a comprehensive library of human, mouse, and rat siRNAs in vector or pre-packaged AAV formats (serotypes 1–11) for tissue-specific knockdown.
Search our collection of siRNA Technology products using Gene symbol or Accession number:
Advantages of AAV siRNA:
- Utilizes potent 27-29 bp oligos compared to traditional 19 or 21 bp oligos.
- Features convergent promoters to eliminate hairpin loop structures, simplifying sequencing and plasmid propagation.
- Includes GFP reporter for real time monitoring of transfection or viral infection.
- Available as a pooled set of 3 constructs for enhanced gene knockdown.
- AAV delivery results in low immunogenicity and no genomic integration.
Additional Information
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AAV Serotype Selection Chart -
Vector Map -
Workflow
Documents
Top Publications
FSH blockade improves cognition in mice with Alzheimer’s disease.
Xiong J. et al.
Nature (2022)
doi: 10.1038/s41586-022-04463-0
Hepatic TET3 contributes to type-2 diabetes by inducing the HNF4α fetal isoform.
Dai Li. et al.
Nature Communications (2020)
doi: 10.1038/s41467-019-14185-z
Sphingosine-1-phosphate receptor 3 in the medial prefrontal cortex promotes stress resilience by reducing inflammatory processes.
Corbett BF. et al.
Nature Communications (2019)
doi: 10.1038/s41467-019-10904-8