PD0325901
| Cat. No. | G7204 |
| Name | PD0325901 |
| Description |
PD0325901 is a highly potent and selective inhibitor of MEK1 and MEK2, key kinases in the MAPK/ERK signaling pathway. By blocking MEK activity, PD0325901 prevents ERK phosphorylation and downstream signaling, making it an essential tool for regulating proliferation, differentiation, and survival pathways in mammalian cells. In stem cell biology, PD0325901 is frequently used in combination with CHIR99021 (the "2i" system) to support naïve pluripotent stem cell maintenance, stabilize iPSC cultures, and enhance reprogramming efficiency. It is also widely applied in cancer research, developmental biology, and signal transduction studies. Key Features:
Applications:
Specifications:
|
| Unit | 1 mg |
| Usage |
Typical iPSC use: 0.5–1 µM (optimization required) |
| Appearance | White to off-whi |
| Storage Condition | Powder stable at –20 °C, protect from light. |
| Material Citation | If use of this material results in a scientific publication, please cite the material in the following manner: Applied Biological Materials Inc, Cat. No. G7204 |