SB431542 (Hydrate)
| Cat. No. | G7203 |
| Name | SB431542 (Hydrate) |
| Description |
SB431542 (Hydrate) is a potent and selective inhibitor of the TGF-β type I receptor (ALK5), as well as ALK4 and ALK7, making it a valuable tool for studying TGF-β/SMAD signaling pathways. By blocking TGF-β signaling, SB431542 prevents differentiation and promotes the self-renewal and expansion of human pluripotent stem cells. This small molecule is widely used in iPSC reprogramming protocols, where it enhances efficiency and stabilizes pluripotency, and in directed differentiation workflows, particularly for generating neural, cardiac, and endodermal cell types. Its high specificity and reproducible performance make it a standard reagent in stem cell biology and regenerative medicine research.
Key Features:
Applications:
Specifications:
|
| Unit | 10 mg |
| Usage |
Typical iPSC use: 2–10 µM (optimization required) |
| Appearance | Light yellow to |
| Storage Condition | Store powder at –20 °C, light-protected. |
| Material Citation | If use of this material results in a scientific publication, please cite the material in the following manner: Applied Biological Materials Inc, Cat. No. G7203 |