Recombinant Human PTHLH/PTHrP (E. coli)

Cat. No.

Z103135

Unit

Price

$113.00

Cat. No.	Z103135
Name	Recombinant Human PTHLH/PTHrP (E. coli)
Description	PTHLH is a member of the parathyroid hormone family which regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth via its receptor, PTHR1. In most cases of humoral hypercalcemia of malignancy, PTHLH is responsible. Alternatively spliced transcript variants have been found for this gene and mutations in this gene are also associated with brachydactyly type E2 (BDE2). Furthermore, evidence have been found for alternative translation initiation from non-AUG (CUG and GUG) start sites, downstream of the initiator AUG codon, resulting in nuclear forms of this hormone.
Organism	Human (H. sapiens)
Unit quantity	20 µg
Family	Other Growth Factors/Cytokines
Aliases	BDE2, HHM, PLP, PTHR, PTHRP
Gene Symbol	PTHLH
Gene ID	5744
Accession Number	P12272
Source	E. coli
Species	Human (H. sapiens)
Appearance	Lyophilized Powder
Molecular Weight	10.2 kDa
Endotoxin Level	<1.0 EU/µg of recombinant protein as determined by the LAL method
Purity	>95% as determined by SDS-PAGE
Formulation	Lyophilized from 0.2 μm filtered solution in PBS
Function	The ED(50) was determined by the dose-dependent proliferation of Immortalized Human Endometrial Stromal Cells (HESC) and was found to be <0.05ng/mL.
Reconstitution	A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.
Storage	The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.
Material Citation	If use of this material results in a scientific publication, please cite the material in the following manner: Applied Biological Materials Inc, Cat. No. Z103135

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How do I choose the right growth factor for my experiment?

Cell type: Different cells respond to different growth factors. Choose a growth factor that promotes the growth or differentiation of your target cell type.
Desired outcome: Whether you are studying proliferation, differentiation, or survival, different growth factors will promote different cellular behaviors.
Concentration and formulation: Different experiments may require varying concentrations of growth factors.

Check out Role of Growth Factors in Cell Differentiation.

	What is the shelf life and storage condition of this product?
	The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.