SensiStain™ Anti-TIGIT Antibody
| Cat. No. | HY500240 |
| Name | SensiStain™ Anti-TIGIT Antibody |
| Clone | IHC498 |
| Category | IHC Antibodies |
| Gene Name | TIGIT |
| Application | ELISA,IHC |
| Raised In | Rabbit |
| Clonality | Monoclonal |
| Reactivity | Human |
| Description |
TIGIT is an immune receptor present on some T cells and Natural Killer cells. TIGIT binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells. Through the CD226/TIGIT-PVR pathway, TIGIT regulates T cell mediated immunity. In cancer, TIGIT and PD-1 have been shown to be over-expressed on tumor antigen-specific CD8+ T cells and CD8+ tumor infiltrating lymphocytes (TILs) from individuals with melanoma. Blockade of TIGIT and PD-1 led to increased cell proliferation, cytokine production, and degranulation of tumour antigen-specific CD8+ T cells and TIL CD8+ T cells. It can be considered an immune checkpoint. |
| Immunogen | Recombinant Protein |
| Isotype | IgG |
| Uniprot Number | Q495A1 |
| Recommended Dilutions |
1:50-1:200 |
| Storage Buffer | Tris Buffer, pH 7.3 - 7.7, with 1% BSA and <0.1% Sodium Azide |
| Storage Condition |
This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. For extended storage aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing. |
| Material Citation | If use of this material results in a scientific publication, please cite the material in the following manner: Applied Biological Materials Inc, Cat. No. HY500240 |